KMID : 0043319880110020134
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Archives of Pharmacal Research 1988 Volume.11 No. 2 p.134 ~ p.138
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Development of Reagent for Cancer Diagnosis by Urine Color Reaction (I)-Comparative analysis of cancer and non-cancer urine by NMR, HPLC and Gift reagent
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Park MK
Yang JS/Lee MY/Kim YK/Weon NH/Kim YD
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Abstract
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Urine measurements by NMR were made for 25 persons including cancer and non-cancer patients. The aromatic proton signals of NMR were observed much more often in cancer patients¡¯¡¯ urine than non-cancer patients¡¯¡¯ one. To compare the amount of the phenolic compounds excreted in urine between cancer and non-cancer patient, urine analysis by HPLC with UV detector was performed. Total peak area and major peak areas of cancer patients¡¯¡¯ urine were much greater than those of non-cancer patients¡¯¡¯ one. To check the phenolic compound excreted in urine, a new jellied reagent named Gift reagent which was based on Millon¡¯¡¯s reagent, was developed for urine color reaction. When the reagent was tested, the sensitivity and specificity for urine samples of 69 persons including cancer and non-cancer patients were measured by 85.3% and 91.4%, respectively, indicating that the Gift reagent afford a possibility of cancer diagnosis.
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KEYWORD
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